Mitochondrially mediated synergistic cell killing by bile acids
نویسندگان
چکیده
منابع مشابه
Mitochondrially-mediated toxicity of bile acids.
In the healthy hepatocyte, uptake of bile acids across the basolateral membrane and export via the canalicular export pump, are tightly coupled. Impairment of bile formation or excretion results in cholestasis, characterized by accumulation of bile acids in systemic blood and within the hepatocyte. When the concentration of bile acids exceeds the binding capacity of the binding protein located ...
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It is now well established that NK cells recognize classical and nonclassical MHC class I molecules and that such recognition typically results in the inhibition of target cell lysis. Given the known structural similarities between MHC class I and non-MHC-encoded CD1 molecules, we investigated the possibility that human CD1a, -b, and -c proteins might also function as specific target structures...
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Giardia lamblia trophozoites were killed in vitro by 1% fresh human milk in the presence of bile. A similar effect was achieved in the absence of bile with milk which had been stored for at least 24 h at 6 degrees C. This killing activity was found to be caused by unsaturated fatty acids. Depending on their chain length and the number of double bonds, the concentrations of unsaturated fatty aci...
متن کامل[Bile acids].
Airaudo ChB, Gayte-Sorbier A, Aujoulat P and Mercier V (1988) Thin-layer chromatography of amine antioxidants and antiozonants used in elastomers. Journal of Chromatography 437: 59}82. FateH r Z, Tasi G, Szabady B and Nyiredy Sz (1998) IdentiRcation of amphetamine derivatives by uni-dimensional multiple development and two-dimensional HPTLC combined with postchromatographic derivatization. Jour...
متن کاملAdvances in bile acids-mediated liver injury and liver regeneration
Bile acids are endogenous molecules that originate from the liver and transport via bile to the intestines. They normally regulate cholesterol homeostasis, stimulate lipid solubilization and mediate metabolic signaling. Early studies implicated that disorders of bile acids compositions and concentrations can cause liver injury. Several hydrophobic bile acids are toxic and ample increases of the...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2003
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(02)00224-7